Green-lipped mussel's therapeutic uses

  • DEFINITION: Natural seafood product used to treat specific health conditions.
  • PRINCIPAL PROPOSED USE: Osteoarthritis
  • OTHER PROPOSED USES: Asthma, rheumatoid arthritis, other inflammatory conditions, immune booster

Overview

Green-lipped mussels, a common appetizer in sushi restaurants, contain healthy fats in the omega-3 family. Like fish oil, another source of omega-3 fatty acids, green-lipped mussels have shown some promise for reducing inflammation. Inflammation is the cause of symptoms in numerous illnesses, ranging from arthritis to asthma to chronic health conditions. On this basis, green-lipped mussels have been promoted as a treatment for these conditions. However, the evidence that they provide any meaningful benefits remains highly preliminary.

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Therapeutic Dosages

A typical dose of green-lipped mussel is about 200 milligrams (mg) per day of the lipid extract or 1,000 mg daily of the freeze-dried powder.

Therapeutic Uses

There are two major forms of arthritis: osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is primarily a disease of inflammation, and the anti-inflammatory omega-3 fatty acids found in fish oil have been successfully used to treat it. Inflammation plays a relatively less important role in osteoarthritis. Green-lipped mussels have been tried for both conditions, and a 2021 study showed conclusive evidence of green-lipped mussels' ability to relieve pain and reduce inflammation effectively.

Unlike standard nonsteroidal anti-inflammatory drugs (NSAIDs), which harm the stomach wall, green-lipped mussels might help prevent ulcers. They have also been shown to ease asthma. Green-lipped mussels are also being explored to treat other inflammatory conditions, such as irritable bowel disease and tendinitis. 

Scientific Evidence

Arthritis. The evidence regarding using green-lipped mussel for arthritis remains weak and inconsistent. Several animal studies performed by a single research group have reported that green-lipped mussel reduces symptoms of osteoarthritis. However, the results from human studies remain inconsistent. Only a few reported controlled studies of green-lipped mussel for osteoarthritis found benefits. One study published in 2017 found that green-lipped mussel supplementation reduced pain and improved the quality of life of study participants with osteoarthritis of knee and hip osteoarthritis. 

Asthma. In an eight-week, double-blind, placebo-controlled trial of forty-six people with allergic asthma, those who received a green-lipped mussel extract showed some improvement in wheezing and peak air flow. While further study appeared to confirm the green-lipped mussel’s ability to reduce asthma symptoms and act as an anti-inflammatory, more studies are needed.

Small-scale studies have also shown that green-lipped mussels may be effective in treating muscle soreness in athletes and attention deficit hyperactivity disorder in children, but more studies are needed to confirm these findings.

Safety Issues

In studies, green-lipped mussel has not caused many side effects other than occasional mild digestive distress. People with shellfish allergies, however, should avoid green-lipped mussel. Unlike oysters, green-lipped mussel does not appear to contain heavy metals.

Bibliography

Abshirini, Maryam, et al. "Effect of Greenshell™ Mussel on Osteoarthritis Biomarkers and Inflammation in Healthy Postmenopausal Women: A Study Protocol for a Randomized Double-Blind Placebo-Controlled Trial." Trials, vol. 22, no. 498, 2021, doi.org/10.1186/s13063-021-05473-5. Accessed 24 Sept. 2024.

Abshirini, Maryam, et al. "Green-lipped (Greenshell™) Mussel (Perna Canaliculus) Extract Supplementation in Treatment of Osteoarthritis: A Systematic Review." Inflammopharmacology, vol. 29, no. 4, 2020, pp. 925-938, doi.org/10.1007/s10787-021-00801-2. Accessed 21 Aug. 2023.

Cho, S. H., et al. "Clinical Efficacy and Safety of Lyprinol, a Patented Extract from New Zealand Green-Lipped Mussel (Perna canaliculus) in Patients with Osteoarthritis of the Hip and Knee." Allergie et Immunologie, vol. 35, 2003, pp. 212-216.

Cobb, C. S., and E. Ernst. "Systematic Review of a Marine Nutriceutical Supplement in Clinical Trials for Arthritis: The Effectiveness of the New Zealand Green-Lipped Mussel Perna canaliculus." Clinical Rheumatology, vol. 25, no. 3, 2006, pp. 275-284.

Emelyanov, A., et al. "Treatment of Asthma with Lipid Extract of New Zealand Green-Lipped Mussel." European Respiratory Journal, vol. 20, 2002, pp. 596-600.

"Green-Lipped Mussel – Health Information Library." PeaceHealth, 5 June 2015, www.peacehealth.org/medical-topics/id/hn-2860000. Accessed 24 Sept. 2024.

Halpern, G. M. "Anti-Inflammatory Effects of a Stabilized Lipid Extract of Perna canaliculus (Lyprinol)." Allergie et Immunologie, vol. 32, 2000, pp. 272-278.

Marengo, Katherine and Gavin Van De Walle. "Green-Lipped Mussel Supplements: All You Need to Know." Healthline, 1 Feb. 2021, www.healthline.com/nutrition/green-lipped-mussel. Accessed 24 Sept. 2024.

Rojas de Astudillo, L., et al. "Heavy Metals in Green Mussel (Perna viridis) and Oysters (Crassostrea) from Trinidad and Venezuela." Archives of Environmental Contamination and Toxicology, vol. 42, 2002, pp. 410-415.