Natural treatments for aging skin

DEFINITION: Treatment of skin changes caused by aging and skin damage caused by long-term exposure to the sun.

• PRINCIPAL PROPOSED NATURAL TREATMENTS: Alpha-hydroxy acids, antioxidants (carotenoids, green tea, milk thistle, oligomeric proanthocyanidin complexes, selenium, soy isoflavones, vitamin C, vitamin E)
• OTHER PROPOSED NATURAL TREATMENTS: Acupuncture, aloe, Arnica, beta-carotene, calendula, chamomile, coriander oil, dead sea minerals, dehydroepiandrosterone, glucosamine, gotu kola, “growth hormone enhancers,” IGF-1, IGF-2, TGF-A, and other growth factors, niacinamide, para-aminobenzoic acid, silicon, thuja, vitamin A, Vitis vinifera
• HERBS AND SUPPLEMENTS TO USE WITH CAUTION: St. John’s wort; vitamin A (among people using tretinoin)

Introduction

The substances collagen and elastin give skin its firmness and elasticity. With age, though, the collagen and elastin content of the skin gradually decreases. As a result, the skin becomes looser, weaker, less elastic, and drier. In addition, the fat pads under the skin begin to disappear. Wrinkles form, and the skin begins to sag.

This gradual loss of structure has several causes: genetic programming (a built-in “clock” that causes aging), cumulative sun damage (photoaging), and direct chemical effects from cigarette smoking or abrasive chemicals, or both. Sun damage also causes fine wrinkles that disappear when stretching the skin, surface roughness, mottled pigmentation, “liver” spots, and skin cancer.

In people who already have signs of aging skin and wish to reverse it, a number of treatments are available. The prescription topical drug tretinoin (retinoic acid, or Retin-A), a substance related to vitamin A, has been shown effective for reversing the fine wrinkles, splotchy pigmentation, and rough skin of sun damage. The hormone estrogen is thought to help restore normal skin tone in menopausal women, but the evidence for this widely held belief remains weak.

More aggressive treatments for aging skin include injections of botulinum toxin, dermabrasion, chemical peels, soft tissue augmentation, laser resurfacing, and Gore-Tex threads.

Principal Proposed Natural Treatments

Two classes of natural treatments have shown promise in the treatment of aging skin: alpha-hydroxy acids (AHAs) and antioxidants. However, the evidence that they work remains incomplete, and AHAs can cause significant side effects.

Alpha-hydroxy acids. Alpha-hydroxy acids, such as glycolic acid and lactic acid, are substances derived from fruit and dairy products. These are milder relatives of the substances used by dermatologists in chemical peels, which are designed to remove damaged layers of the skin. Cosmetics manufacturers are now adding AHAs to many skin-care products.

Meaningful evidence in support of AHAs was found in a double-blind, placebo-controlled study reported in 1996. This twenty-two-week study enrolled seventy-four women with sun-damaged skin. Participants received either 8 percent glycolic acid, 8 percent L-lactic acid, or placebo cream and applied it to the face and forearm. Although participants showed improvements in each of the three groups, superior results were achieved with each of the AHA creams than with the placebo cream. Another double-blind study compared estrogen cream, glycolic acid cream, and their combination with placebo. Both estrogen and glycolic acid improved skin aging.

AHAs are not always harmless. Possible side effects include burning, blistering, severe redness, swelling (especially in the area of the eyes), bleeding, rash, and increased sensitivity to the sun. There are also concerns that AHAs may increase the risk of skin cancer. For all these reasons, the U.S. Food and Drug Administration continues to investigate the use of AHAs in cosmetic products to determine whether they should be reclassified as drugs.

Antioxidants. The ultraviolet light from the sun creates free radicals, naturally occurring substances that can harm many tissues of the body, including the skin. Antioxidants are substances that neutralize free radicals. On this basis, various antioxidants have been investigated for their potential usefulness in treating or preventing photoaging.

A small, three-month, double-blind, placebo-controlled study found benefit with a cream containing 5 percent alpha-lipoic acid. The use of this antioxidant substance improved several measures of aging skin especially skin roughness, compared with placebo. Benefits have also been seen in preliminary studies with a cream containing vitamin C. In a small double-blind study, the use of mixed antioxidants (lycopene, beta-carotene, vitamin E, and selenium) for twelve weeks improved skin roughness and scaling.

Oligomeric proanthocyanidin complexes (OPCs) made from grape seed or pine bark are widely marketed for the treatment of aging skin. These substances, closely related to bioflavonoids, have antioxidant properties and might also protect and strengthen collagen and elastin. These effects provide theoretical reasons to believe that OPCs might be helpful for the treatment of aging skin. However, despite widespread marketing, no properly designed studies have been reported to indicate that OPCs provide any benefit.

In an eight-week, double-blind, placebo-controlled study of forty women who already had sun-damaged skin, the combined use of oral green tea and a topical green tea cream failed to prove more effective than placebo in improving the condition of sun-damaged skin. Some possible benefits were seen in microscopic evaluation of skin conditions.

Studies on laboratory animals found that topical vitamin C and vitamin E helped prevent burning on exposure to ultraviolet light. A small double-blind study found that 2 grams (g) of vitamin C and 1,000 international units (IU) of vitamin E taken orally for eight days resulted in a modest decrease of sunburn induced by ultraviolet light. In addition, a fifty-day, placebo-controlled study of forty people found that higher doses of these vitamins provided a sun protection factor (SPF) of about 2.16. (The sun protection factor is 15 or higher in many sunscreens.) It appears that these vitamins must be taken together for best effect; when used alone, they do not appear to work.

The oral use of beta-carotene, lycopene, and other carotenoids has shown preventive effects in some studies. Benefits have also been seen with mixtures of various antioxidants taken together (vitamin E, zeoxanthin, lutein, beta-carotene, and others).

Oral vitamin A has shown some promise for preventing skin cancer in people at risk for it, but the doses used in studies were quite high, considerably above recommendations for the maximum safe dose. Vitamin A should not be used with the drug tretinoin.

Topical vitamin A may be helpful for treatment of aging skin. One double-blind, placebo-controlled study found that a 0.4 percent vitamin A lotion applied three times a week significantly reduced the number of “fine” wrinkles in seniors. Benefits were also seen in terms of some biochemical measures of skin health.

Because these antioxidants work in an entirely different manner from standard sunscreen, it is reasonable to believe that they could offer a synergistic effect if taken while using sunscreen. However, this hypothesis has not been studied.

Other substances with antioxidant actions that have shown some promise for treating or preventing aging skin include cocoa, Vitis vinifera extract, milk thistle, and zinc. However, the supporting evidence that the use of these substances (taken either orally or topically) offers any benefit for the skin remains far too preliminary to be relied upon.

Any discussion of the potential benefits of antioxidants for preventing cancer must include the startling finding of a large study that tested the effect of mixed antioxidants. This trial, enrolling 7,876 women and 5,141 men, evaluated the potential benefits of a combination of vitamin C, vitamin E, beta-carotene, selenium, and zinc for preventing cancer. According to results published in 2007, no benefits were seen among the male participants, but among women, skin cancer rates actually appeared to increase. The cause of these findings remains unclear.

Other Proposed Natural Treatments

In a double-blind study of fifty women with signs of aging skin, the use of topical niacinamide cream significantly improved skin appearance and elasticity compared with placebo cream. A study published in 2007 tested a purified soy isoflavone product (technically, isoflavone aglycones) for treatment of aging skin. In this double-blind trial, twenty-six Japanese women in their late thirties and early forties were given either placebo or 40 milligrams (mg) daily of soy isoflavone aglycones for twelve weeks. Researchers monitored two types of wrinkles near the eye: “fine” wrinkles and “linear” wrinkles. The results indicated that the use of the soy product significantly reduced fine wrinkles compared with placebo. (Effects on linear wrinkles were not significant.) As a secondary measure, researchers also analyzed skin elasticity and found an improvement in the women given the isoflavones compared to those given placebos.

An unusual soy extract containing soybean trypsin inhibitor and Bowman-Birk protease inhibitor has also shown promise for aging skin. Sixty-five women with moderate skin damage from the sun received either soybean extract or placebo cream for twelve weeks. Compared to the women in the placebo group, treated women showed an improvement in mottled pigmentation, blotchiness, dullness, and fine lines, and an overall enhancement of texture, skin tone, and appearance.

The substance glucosamine is widely used for osteoarthritis, in part because it seems to help collagen regenerate. For this reason, it has been advocated as a treatment for aging skin. However, the only evidence that it works comes from one poorly designed study. In this single-blind trial, seventy-two women with symptoms of aging skin were divided into two unequal groups: a small group that received no treatment and a much larger one that received a proprietary mixture of glucosamine, amino acids, and minerals. The results indicated greater improvement in the treated group compared to the untreated group. However, because this was not a double-blind, placebo-controlled study, the results cannot be taken as reliable.

The mineral silicon also has been proposed as a treatment for aging skin. In the one potentially meaningful published study, fifty women with sun-damaged skin were given either 10 mg silicon daily (as orthosilicic acid) or placebo for twenty weeks. Measurements of skin roughness and elasticity showed improvement in the silicon group compared with the placebo group. However, this study, performed by the manufacturer of a silicon product, was not well designed or well reported.

A proprietary dietary supplement containing soy, fish protein polysaccharides, white tea extract, and many other ingredients has also shown promise, according to a study performed by the manufacturer. Another study provides weak evidence that the substance DHEA (dehydroepiandrosterone) might be helpful for improving skin condition in the elderly.

In a preliminary double-blind study, coriander oil applied topically was more effective than a placebo cream at reducing redness from UVB exposure. This effect may or may not translate into long-term benefits for aging sun-damaged skin.

Numerous herbs and other natural products have been advocated for the treatment of aging skin. These products include aloe, Arnica, calendula, chamomile, dead sea minerals, gotu kola, para-aminobenzoic acid, thuja, and vitamin A. Other products claim to contain biological substances called growth factors (with names such as IGF-1, IGF-2, TGF-A, TGF-B, EGF, and FGF) and go on to claim that these growth factors improve skin condition. Still others claim to raise levels of human growth hormone in the body and, therefore, help produce youthful skin. However, there is no meaningful evidence that any of these treatments work.

Acupuncture face lifts are widely available for treating facial wrinkles. They involve a series of treatments in which fine needles are inserted into the face. However, there is no evidence to indicate that this method produces any benefit.

Herbs and Supplements to Use with Caution

The herb St. John’s wort contains a substance, hypericin, that increases the skin’s sensitivity to the sun. For this reason, it is possible that the use of St. John’s wort could accelerate sun damage of skin. Also, persons using the drug Retin-A should not take high doses of vitamin A, as each might increase the toxicity of the other.

Bibliography

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