Natural treatments for cervical dysplasia

  • DEFINITION: Treatment of the precancerous stages of cervical cancer.
  • PRINCIPAL PROPOSED NATURAL TREATMENTS: None
  • OTHER PROPOSED NATURAL TREATMENTS: Black cohosh, blessed thistle, dehydroepiandrosterone, diindolylmethane, emmenagogue herb, false unicorn, folate, indole-3-carbinol, motherwort, multivitamin/mineral supplements, selenium, squaw vine, true unicorn

Introduction

Few cancers can be identified so far ahead of the danger point as cancer of the cervix. A decade or more before invasive cancer develops, the cells lining the surface of the cervix begin to show changes visible under a microscope–in plenty of time for definitive treatment. For this reason, a regular, properly performed and interpreted Pap test is one of medicine’s most effective preventive methods.

The stages of progression from a healthy cervix to one that is cancerous begin with what is called mild dysplasia: precancerous alterations in structure and activity. Prolonged infection with human papillomavirus (HPV) is thought to be the primary cause of these changes. Subsequently, altered cells spread from the surface of the cervix down toward the underlying tissue. In the early stages, cancerous changes may disappear on their own, but once these cells fully penetrate the lining, progression to true cancer usually occurs within five to ten years.

Medical treatment consists of watchful waiting for spontaneous regression during the early stages of dysplasia and, if no regression occurs, more aggressive removal of the cervical lining by laser, freezing, or other techniques. These options are usually successful; however, they are invasive and frequently uncomfortable. The HPV vaccine has been shown to significantly reduce cancer risk, particularly for cervical cancer and other HPV-related cancers.

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Proposed Natural Treatments

It has been claimed that certain natural herbs and supplements can improve the odds of early stages of dysplasia returning to normal cells. If a woman’s physician suggests watchful waiting and a repeat examination, it should be safe to try some of these methods during the waiting period. There is, however, no reliable scientific evidence that these treatments are effective, and in all circumstances, close medical supervision is necessary to verify good results or identify failure. Alternative treatment is definitely not advisable for advanced cervical dysplasia.

Folate deficiency is thought to increase the ease with which cervical cancer can develop. However, taking extra folate does not appear to reverse cervical dysplasia once it has occurred. Indole-3-carbinol (I3C) is a substance found in vegetables in the broccoli family. One small, double-blind, placebo-controlled trial found evidence that I3C at a dose of 200 or 400 milligrams (mg) per day can improve the chances of cervical dysplasia returning to normal by itself. The related substance diindolylmethane might also help.

Observational studies have found that women with cervical dysplasia tend to show a high frequency of general nutritional deficiencies, as high as 67 percent in one survey. Particular vitamin deficiencies most closely associated with cervical dysplasia include beta-carotene, vitamin C, vitamin B6, selenium, and folate. However, observational studies are notoriously unreliable; it is quite possible, for example, that people who do not eat healthily also have other risk factors for cervical dysplasia. Only double-blind, placebo-controlled studies can actually show a treatment effective, and these have not been promising. For example, a double-blind, placebo-controlled study of 141 women found that neither vitamin C nor beta-carotene supplements taken daily in doses of 500 mg and 30 mg, respectively, could reverse cervical dysplasia. Negative results were also seen in studies that investigated beta-carotene by itself.

Some practitioners of herbal medicine feel that a class of herbs known as emmenagogues can be helpful in cervical dysplasia. These include squaw vine, motherwort, true unicorn, false unicorn, black cohosh, and blessed thistle. However, there is no meaningful scientific evidence to indicate that any of these herbs are effective for cervical dysplasia. Vaginal use of the hormone dehydroepiandrosterone has also been suggested for the treatment of early cervical dysplasia, but no controlled studies have been reported.

Bibliography

Bell, Maria C., et al. "Placebo-Controlled Trial of Indole-3-Carbinol in the Treatment of CIN." Gynecologic Oncology, vol. 78, no. 2, 2000, pp. 123-129.

Bruno, Maria T., et al. "Spontaneous Regression of Cervical Intraepithelial Neoplasia 3 in Women with a Biopsy—Cone Interval of Greater than 11 Weeks." BMC Cancer, vol. 22, 2022, p. 1072, doi.org/10.1186/s12885-022-10179-1. Accessed 20 Nov. 2024.

“Cervical Dysplasia - Complementary and Alternative Medicine.” St. Luke's Hospital, 29 Sept. 2015, www.stlukes-stl.com/health-content/medicine/33/000034.htm. Accessed 20 Nov. 2024.

Keefe, Kimlin A., et al. "A Randomized, Double Blind, Phase III Trial Using Oral Beta-Carotene Supplementation for Women with High-Grade Cervical Intraepithelial Neoplasia." Cancer Epidemiology, Biomarkers & Prevention, vol. 10, no. 10, 2001, pp. 1029-1035.

“Large Study Confirms HPV Vaccine Prevents Cervical Cancer.” National Cancer Institute, 14 Oct. 2020, www.cancer.gov/news-events/cancer-currents-blog/2020/hpv-vaccine-prevents-cervical-cancer-sweden-study. Accessed 20 Nov. 2024.

Mackerras, Dorothy, et al. "Randomized Double-Blind Trial of Beta-Carotene and Vitamin C in Women with Minor Cervical Abnormalities." British Journal of Cancer, vol. 79, no. 9, 1999, pp. 1448-1453.

Park, Seung-Hyeok, et al. "Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review." Nutrients, vol. 13, no. 1, Jan. 2021, p. 154. doi.org/10.3390/nu13010154. Accessed 20 Nov. 2024.

Šarenac, Tanja, and Momir Mikov. "Cervical Cancer, Different Treatments and Importance of Bile Acids As Therapeutic Agents in This Disease." Frontiers in Pharmacology, vol. 10, 2019, p. 484, doi.org/10.3389/fphar.2019.00484. Accessed 20 Nov. 2024.

Suh-Burgmann, Elizabeth, et al. "Long-Term Administration of Intravaginal Dehydroepiandrosterone on Regression of Low-Grade Cervical Dysplasia." Gynecologic and Obstetric Investigation, vol. 55, no. 1, 2003, pp. 25-31.

Zoorob, Roger J. "CAM and Women's Health: Selected Topics." Primary Care, vol. 37, no. 2, 2010, pp. 367-387.