Plantain's therapeutic uses

DEFINITION: Natural plant product used to treat specific health conditions.

PRINCIPAL PROPOSED USES: None

OTHER PROPOSED USES: Anti-inflammatory, chronic bronchitis, skin conditions, antimicrobial, digestive health, antioxidant, blood sugar control, anti-hemorrhagic

Overview

Plantain (not to be confused with the relative of the banana known by the same name) is a small weed often found in cultivated fields and at the edge of lawns. Traditionally, the crushed leaves were applied to the skin to treat wounds and bites, a leaf tincture was used for coughs, and the dried leaf was taken internally to treat bronchitis, ulcers, epilepsy, and liver problems.

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Therapeutic Dosages

A typical oral dose of plantain is 1 to 3 grams (g) three times daily. Syrups and tinctures are used for coughs.

Plantain contains active substances in the iridoid glycoside family, especially aucubin, catalpol, and acteoside. The highest levels are found when the plant is collected in mid-fall. Other potentially active ingredients fall in the phenolic category, such as caffeic acid. Some plantain products are standardized to levels of one or more of these ingredients, but it is not clear whether this produces a better product.

Therapeutic Uses

Evidence indicates that topical plantain is helpful for skin conditions, including poison ivy and eczema. It may also soothe minor skin conditions such as insect bites, rashes, and minor burns. One double-blind, placebo-controlled study found plantain helping for treating atopic dermatitis in children. Evidence from two studies performed in Bulgaria hints that oral plantain may be helpful for chronic bronchitis. Its expectorant properties have also been shown to help coughs and colds in studies. 

Plantain extracts do appear to have anti-inflammatory effects, at least in the test tube. However, unlike most pharmaceutical anti-inflammatory drugs, which work on the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) systems, one study suggests that plantain may work differently by decreasing levels of nitric oxide. Whether this indicates any real potential benefit in people remains unknown.

Other possible actions of plantain constituents based on test-tube studies include anticancer effects and antiviral actions. Contrary to some reports, one study found that plantain does not have diuretic (kidney-stimulating) effects. Plantain does appear to promote digestive health due to it containing psyllium, a type of fiber that is often used as a natural laxative. Plantain’s digestive health benefits also may combine with its anti-inflammatory properties to help control the symptoms of irritable bowel syndrome (IBS). Its astringent effects may help with diarrhea and be an effective treatment for gastritis and stomach ulcers. 

Plantain's antioxidant properties may help protect against free radicals, which can lead to chronic health conditions. Studies indicated it may also play a role in managing blood sugar, suggesting plantain could play a pivotal role in diabetes management. Traditionally, plantain was used to control bleeding.

Safety Issues

Plantain appears to be relatively safe, but comprehensive safety studies have not been performed. Plantain grown in soil contaminated with heavy metals such as thallium or antimony may develop relatively high concentrations of these potential toxins. Safety in pregnant or nursing women, young children, and individuals with liver or kidney disease has not been established. In 1997, the FDA reported that some plantain available for sale on the herb market was contaminated with similar-appearing foxglove (digitalis), an herb with potent and potentially toxic effects on the heart.

Bibliography

Baroni, F., et al. "Antimony Accumulation in Achillea ageratum, Plantago lanceolata, and Silene vulgaris Growing in an Old Sb-Mining Area." Environmental Pollution, vol. 109, 2004, pp. 347-352.

Chiang, L. C., et al. "Antiviral Activity of Plantago major Extracts and Related Compounds In Vitro." Antiviral Research, vol. 55, 2002, pp. 53-62.

Galvez, M., et al. "Cytotoxic Effect of Plantago spp. on Cancer Cell Lines." Journal of Ethnopharmacology, vol. 88, 2003, pp. 125-130.

Gomez-Flores, R., et al. "Immunoenhancing Properties of Plantago major Leaf Extract." Phytotherapy Research, vol. 14, 2001, pp. 617-622.

Hatanaka, Miho. "What Is Plantain Weed, and How Do You Use It?." Healthline, 10 June 2020, www.healthline.com/nutrition/plantain-weed. Accessed 19 Sept. 2024.

Herold, A., et al. "Hydroalcoholic Plant Extracts with Anti-inflammatory Activity." Roumanian Archives of Microbiology and Immunology, vol. 62, 2004, pp. 117-129.

"Plantain – Health Information Library." PeaceHealth, 24 May 2015, www.peacehealth.org/medical-topics/id/hn-2148003. Accessed 19 Sept. 2024.

"Plantain Uses, Benefits & Side Effects." Drugs.com, www.drugs.com/npc/plantain.html. Accessed 19 Sept. 2024.

Tamura, Y., and S. Nishibe. "Changes in the Concentrations of Bioactive Compounds in Plantain Leaves." Journal of Agricultural and Food Chemistry, vol. 50, 2002, pp. 2514-2518.

Vigo, E., et al. "In-Vitro Anti-inflammatory Activity of Pinus sylvestris and Plantago lanceolata Extracts: Effect on Inducible NOS, COX-1, COX-2 and Their Products in J774A.1 Murine Macrophages." Journal of Pharmacy and Pharmacology, vol. 57, 2005, pp. 383-391.