Brain scans and cancer

DEFINITION: Computed tomography (CT) scan and magnetic resonance imaging (MRI) are two widely used methods of scanning the brain to distinguish normal tissue from abnormal tissue (tumors or masses). The CT scanner uses X-rays and ionizing radiation (dye) to acquire images of bone and tissue. MRI acquires images using nonionizing radio-frequency signals and is best suited for noncalcified (soft) tissue. CT and MRI scanners generate multiple two-dimensional cross-sections, or “slices,” of tissue and produce three-dimensional reconstructions. For purposes of brain tumor detection and identification, MRI is generally superior. However, CT is typically more available, faster, and much less expensive, and it may be less likely to require the person to be sedated or anesthetized. It can also be performed on people with medical implants such as cochlear implants.

If cancer is suspected, then the CT scan will provide X-ray images of the brain or other internal organs to detect masses or tumors. A dye may be injected into a vein or swallowed to help the organs or tissues appear more clearly. A computer combines the images by “stacking” them on top of each other to offer an exact three-dimensional rendering.

MRI is a procedure that uses magnets and radio waves to send a series of detailed brain images to a computer. A computer then produces cross-sectional or three-dimensional images for evaluation. A substance called gadolinium may be injected into the patient through a vein. The gadolinium collects around the cancer cells so that they show up brighter in the picture. This procedure is also called nuclear magnetic resonance imaging (NMRI).

Other imaging techniques used to detect abnormalities in the brain include positron emission tomography (PET) scans and combined PET/CT scans. Brain PET scans use radioactive sugar to locate and image cells taking up the most energy, thereby helping diagnose and monitor the progression of disease. Sometimes, PET and CT scans are combined to provide a clearer picture of where a tumor is.

Cancers diagnosed:Brain tumor, metastasized cancer

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Why performed: Physicians order brain scans to offer the most precise information available about the brain. The method of scanning depends on the patient's history and examination and the physician's choice of diagnostic testing.

Patient preparation: If the brain scan involves injecting or ingesting a dye, the patient may be asked to avoid eating or drinking for several hours before the exam. All jewelry and metal items must be removed before the brain scan.

Steps of the procedure: The patient will be asked to lie down, place the head in a stabilizer, and remain very still. If contrast (dye) is required, it will be injected through the intravenous (IV) line placed by a radiology nurse or technologist before the exam. During the injection, it is normal for patients to experience a warm sensation throughout the body and a metallic taste in the mouth. Only the head will be covered by the scanner, and those who experience claustrophobia generally do not have problems with a brain scan.

After the procedure: Patients are not restricted after this procedure and may eat and drive as standard.

Risks: The MRI examination poses almost no danger to the average patient; however, if sedation is necessary, a nurse or technologist will monitor vital signs to avoid excessive sedation. The magnetic field is not harmful to the patient, but metal devices nearby can cause malfunctions in the MRI. If dye is injected, there is a rare risk of mild allergic reaction.

In a 2024 article, the National Cancer Institute advised potential recipients of CT scans of the risks, although they are small. There is a risk to an unborn fetus; therefore, CT scanning is not recommended for pregnant women. Nursing mothers must wait twenty-four hours after injecting the dye to return to nursing. There is always a slight chance of cancer from radiation exposure, but the benefit of an accurate diagnosis far outweighs the risk.

Results: A neuroradiologist will read the brain scan, and the results will be shared with the physician for discussion with the patient.

Bibliography

"Brain PET Scan." MedlinePlus, 23 Jan. 2023, medlineplus.gov/ency/article/007341.htm. Accessed 8 July 2024.

Buthiau, Didier, and David Khayat. CT and MRI in Oncology. New York: Springer-Verlag, 1998, Print.

"Computed Tomography (CT) Scans and Cancer." National Cancer Institute, 8 Feb. 2024, www.cancer.gov/about-cancer/diagnosis-staging/ct-scans-fact-sheet. Accessed 8 July 2024.

"Imaging (Radiology) Tests for Cancer." American Cancer Society, 24 June 2024, www.cancer.org/cancer/diagnosis-staging/tests/imaging-tests/imaging-radiology-tests-for-cancer.html. Accessed 8 July 2024.

Lee, Howard S., et al. Cranial and Spinal MRI and CT. 4th ed. New York, McGraw-Hill Professional, 1999.

"Radiation Dose in X-Ray and CT Exams." RadiologyInfo.org., 1 Nov. 2022, www.radiologyinfo.org/en/info/safety-xray. Accessed 8 July 2024.

"Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline." American Society of Clinical Oncology, ascopubs.org/doi/10.1200/JCO.21.0231421 Dec. 2021, Accessed 8 July 2024.

Wolbarst, Anthony Brinton. Looking Within: How X-Ray, CT, MRI, Ultrasound, and Other Medical Images Are Created, and How They Help Physicians Save Lives. Berkeley, University of California Press, 1999.