Candytuft's therapeutic uses

DEFINITION: Natural plant product used to treat specific health conditions.

PRINCIPAL PROPOSED USE: Dyspepsia (in herbal combinations)

OTHER PROPOSED USES: Gastrointestinal side effects caused by medications, irritable bowel syndrome, cardiovascular health

Overview

Candytuft, also known as clown’s mustard, is a white flowering plant originally from Spain. It is a member of the Brassicaceae family, making it a relative of cabbage and broccoli. Traditionally, it was used to treat arthritis, gout, enlarged heart, and asthma. The seeds, stems, roots, and leaves have all been used medicinally.

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Therapeutic Dosages

A typical dosage of the tested candytuft preparation is twenty drops three times daily.

Therapeutic Uses

Candytuft is widely used in Germany for treating dyspepsia, a term for chronic digestive distress that occurs without an identifiable cause, such as an ulcer. Symptoms include stomach discomfort, gas, bloating, belching, appetite loss, and nausea.

Several studies, enrolling more than six hundred participants, have found benefits for dyspepsia with the use of a proprietary herbal combination therapy containing candytuft as the primary ingredient. In addition to dyspepsia, candytuft combinations have shown potential for decreasing the gastrointestinal side effects caused by a variety of medications and for reducing lower digestive tract symptoms of irritable bowel syndrome.

The product tested in these studies has undergone change over time. The original version included along with candytuft, matricaria chamomilla (chamomile) flower, peppermint leaves, caraway, licorice root, and lemon balm. Subsequently, an augmented preparation was tested that utilized a mixture of angelica root, celandine, and milk thistle in addition to the above. This second preparation later became the one the manufacturer used instead of the original. In Germany, this combination of ingredients is marketed by a German company as Iberogast and sold worldwide.

Other proposed therapeutic uses for candytuft include cardiovascular health. Traditionally, candytuft was used for irregular heartbeat or heart palpitations. Scientific study indicates it may have cardiovascular benefits and aid in blood pressure regulation. Candytuft also has antioxidant and anti-inflammatory properties, and it has traditionally been used to treat asthma and coughs.

Scientific Evidence

An eight-week double-blind study of 315 people with functional dyspepsia tested the newer candytuft product and found it significantly more effective than a placebo. This was a high-quality study with adequate design and reporting, and its results strongly indicate that the treatment works.

An earlier double-blind, placebo-controlled trial of 120 people with dyspepsia evaluated the original candytuft combination. The design of this study was excessively complicated. Still, in essence, it found that four weeks of treatment with the product was more effective than a placebo in reducing dyspepsia symptoms.

In another double-blind study, this one enrolling sixty people with dyspepsia, the use of either the original or the newer candytuft herbal combination proved more effective than a placebo. Benefits with the original mixture were also seen in two other double-blind, placebo-controlled studies enrolling about two hundred people. In addition, a double-blind, comparative study found that both candytuft combinations and the standard drug cisapride were equally effective. Although scientific study has confirmed candytuft's efficacy in treating digestive issues, further study is necessary to substantiate its other medical claims.

Safety Issues

The tested candytuft preparation has not resulted in any significant side effects in controlled clinical trials. The studied preparation is manufactured in Germany under more closely regulated conditions than herbal manufacturing in the United States. Formulations made outside Germany might present unrecognized safety risks. Even with the tested product, comprehensive safety studies have not been performed. Safety for pregnant or nursing women, young children, and individuals with severe liver or kidney disease has not been established.

Bibliography

Bolen, Barbara. "Iberogast: Should You Try It for Your IBS?" Verywell Health, 8 Aug. 2023, www.verywellhealth.com/iberogast-for-ibs-4107574#toc-iberogast-ingredients. Accessed 22 Aug. 2023.

Gundermann, K. J., E. Godehardt, and M. Ulbrich. "Efficacy of a Herbal Preparation in Patients with Functional Dyspepsia." Advances in Therapy, vol. 20, 2003, pp. 43-49, doi.org/10.1007/BF02850118.

"Iberis Amara (Bitter Candytuft) – Big Effects Brought about by Small Flowers." Iberogast, www.iberogast.co.za/power-of-nature/iberis-amara. Accessed 7 Sept. 2024.

Khayyal, Mohamed T, et al. "Mechanisms Involved in the Anti-inflammatory and Vascular Effects of Iberis amara Extract." Planta Medica, vol. 81, no. 12-13, 2015, pp. 1097-102, doi:10.1055/s-0035-1546244. Accessed 7 Sept. 2024.

Madisch, A., et al. "Ein Phytotherapeutikum und seine Modifizierte Rezeptur bei Funktioneller Dyspepsie. Ergebnisse einer Doppelblinden Plazebokontrollierten Vergleichsstudie [A plant extract and its modified preparation in functional dyspepsia. Results of a double-blind placebo controlled comparative study]." Zeitschrift fur Gastroenterologie, vol. 39, 2001, pp. 511-517 doi: 10.1055/s-2001-16142.

Melzer, J., et al. "Iberis amara L. and Iberogast: Results of a Systematic Review Concerning Functional Dyspepsia." Journal of Herbal Pharmacotherapy, vol. 4, 2005, pp. 51-59.

Rosch, W., B. Vinson, and I. Sassin. "A Randomized Clinical Trial Comparing the Efficacy of a Herbal Preparation STW 5 with the Prokinetic Drug Cisapride in Patients with Dysmotility Type of Functional Dyspepesia." Zeitschrift fur Gastroenterologie, vol. 40, 2002, pp. 401-408, doi: 10.1055/s-2002-32130.

Von Arnim, U., et al. "STW 5, a Phytopharmacon for Patients with Functional Dyspepsia." American Journal of Gastroenterology, vol. 102, 2007, pp. 1268-1275, doi: 10.1111/j.1572-0241.2006.01183.x.