Clozapine
Clozapine is an atypical antipsychotic medication primarily used to treat schizophrenia and schizoaffective disorders, especially in cases where other antipsychotic treatments have failed. It helps alleviate symptoms such as hallucinations and mood instability by modifying neurotransmitter activity in the brain, particularly through the inhibition of dopamine receptors. Since its introduction in the United States in 1990, Clozapine has been recognized for its unique efficacy, especially in treatment-resistant patients. However, its use requires careful management, including gradual dosage adjustments and regular blood tests to monitor white blood cell counts, as Clozapine can lower these levels and pose risks for individuals with certain blood disorders. Patients may experience side effects such as drowsiness, dizziness, and seizures, necessitating close supervision by healthcare providers. Despite its high cost and some controversy at launch, Clozapine remains a critical option in managing severe psychiatric conditions and has even been shown to help prevent suicides in vulnerable individuals. It is available in both tablet and liquid forms, with specific instructions for usage to ensure safety and effectiveness.
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Clozapine
Clozapine is an atypical antipsychotic medication commonly used to treat schizophrenia and schizoaffective disorders in individuals who resist other types of antipsychotic medications. It reduces hallucinations, clears thinking, and stabilizes moods. Like many antipsychotic medications, Clozapine's dosage must be carefully controlled to avoid negative side effects.
Individuals must slowly increase their prescription to its target level and cannot suddenly stop taking the drug. Clozapine may also lower white-blood-cell count. For this reason, it is not prescribed to many individuals with blood disorders. Doctors may also order individuals prescribed Clozapine to undergo periodic blood tests to monitor their white-blood-cell count.
Overview
Clozapine is a prescription psychiatric medicine used to treat specific mood disorders, schizophrenia, and schizoaffective disorders. The drug alters brain chemistry by modifying neurotransmitters to restore balance in the brain. Clozapine has a mood-stabilizing effect because it slightly inhibits dopamine receptors in the brain.
In most cases, clozapine is used to reduce hallucinations in individuals with schizophrenia and schizoaffective disorders. Schizophrenia is a brain disorder that results in hallucinations, difficulty thinking, difficulty concentrating, and delusions. While there is no cure for the disease, its symptoms can usually be managed with persistent, long-term treatment. In addition to its use as an antipsychotic, clozapine also helps prevent suicide in people having such thoughts or in individuals with a history of self-harm. Users of Clozapine often report feeling better about themselves and the ability to think more clearly.
The medication, which was released in the United States in 1990, was the first antipsychotic considered atypical by medical professionals. Because it functioned in a different manner than other antipsychotic medications, Clozapine was often effective in individuals who proved to be resistant to other antipsychotic medications. When the drug entered the market in the United States, its high price made it controversial within the medical community. However, Clozapine's manufacturers justified the price by pointing out that they had to go through extensive safety testing before the drug could be approved for sale. At that point, Clozapine was also the first new antipsychotic drug released in more than ten years, further justifying its premium pricing.
Clozapine can be taken in liquid or tablet form. Tablets must be taken immediately after their packaging has been opened and must be allowed to dissolve on the tongue. If taken in liquid form, the prescribed dosage should be carefully measured before being ingested.
In some cases, Clozapine causes unpleasant side effects, such as drowsiness, dizziness, and seizures. Clozapine can also reduce white-blood-cell count. For this reason, individuals prescribed Clozapine are often required to have periodic blood tests. To avoid negative side effects, individuals prescribed Clozapine must have their dosage slowly increased or decreased. Taking too much of the medication will result in an increased chance of side effects. Reducing the dosage too quickly will result in withdrawal symptoms, such as headaches, vomiting, and diarrhea.
Bibliography
Citrome, Leslie. "Clozapine for Schizophrenia: Line-Threatening or Life-Saving Treatment?" Current Psychiatry, Dec. 2009, www.mdedge.com/currentpsychiatry/article/65222/clozapine-schizophrenia-life-threatening-or-life-saving-treatment. Accessed 26 Oct. 2017.
"Clozapine." Drugs.com, www.drugs.com/clozapine.html. Accessed 26 Oct. 2017.
"Clozapine." MedicinePlus, 2017, medlineplus.gov/druginfo/meds/a691001.html. Accessed 26 Oct. 2017.
"Clozapine ODT." WebMD, www.webmd.com/drugs/2/drug-5200/clozapine-oral/details#. Accessed 26 Oct. 2017.
Crilly J. "The History of Cloazpine and Its Emergence in the US Market: A Review and Analysis." Hist Psychiatry, 18 Mar. 2007, www.ncbi.nlm.nih.gov/pubmed/17580753.
Kane, John M. "The Underuse of Clozapine in Schizophrenia." Psychiatry Advisor, 15 Apr. 2015, www.psychiatryadvisor.com/schizophrenia-and-psychoses/the-underuse-of-clozapine-in-schizophrenia/article/409292/. Accessed 26 Oct. 2017.
Lindsrom, LH. "The Effect of Long-Term Treatment with Clozapine in Schizoprhenia: A Retrospective Study in 96 Patients Treated with Clozapine for up to 13 Years." Pubmed, May 1988, www.ncbi.nlm.nih.gov/pubmed/3407421. Accessed 26 Oct. 2017.
Parekh, Ranna. "What Is Schizophrenia?" American Psychiatric Association, Jan. 2017, www.psychiatry.org/patients-families/schizophrenia/what-is-schizophrenia. Accessed 26 Oct. 2017.