Nervous system reactions as evidence

DEFINITION: Bodily system that coordinates muscle activity, monitors internal organs, receives and interprets input from sense organs, and initiates actions in response to stimuli.

SIGNIFICANCE: Information regarding the working of the human nervous system can be an important part of forensic evidence in legal cases involving persons whose mental functions and responses may have been impaired by toxins, including drugs or alcohol.

The basic units of the nervous system are specialized cells called neurons that are able to conduct stimuli. Neurons may be divided into three types: sensory neurons, which conduct sensations into the central nervous system; motor neurons, which conduct stimuli from the central nervous system to effector organs and muscles; and association neurons, which communicate stimuli between adjacent neurons.

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Neurons are the only cells in the human body that can conduct stimuli. They exist in an electrical-chemical state that is said to be charged or polarized. When stimulated, the charge on the neuron is momentarily reversed in a process called depolarization or action potential. The action potential (stimulus) is initiated at one end of the neuron, the dendrites, and continues to the other end, the axons, from which neurotransmitters are released into the synapse between the neuron and the next neuron, effector gland, muscle, or organ. Arrival of sufficient quantities of neurotransmitters at the dendrites on the next neuron causes that neuron to exhibit an action potential along its length. In this way, the stimulus is transmitted from neuron to neuron or from neuron to muscle.

Three Nervous Systems in One

The human nervous system can be subdivided into the central nervous system, consisting of the brain and spinal cord; the peripheral nervous system, consisting of nerves that carry information to and from the central nervous system; and the autonomic nervous system, which monitors and maintains internal organs and their functions. The peripheral nervous system contains sensory receptors that respond to information from the external world and the individual’s internal environment and sensory neurons that transfer this information to the central nervous system. It also contains motor neurons that carry information from the central nervous system to voluntary muscles, allowing movement. The peripheral nervous system regulates the activities of the body that are under conscious control. It controls all voluntary systems within the body, except for reflex arcs.

The autonomic nervous system monitors and maintains the body’s internal state. These maintenance activities are performed primarily without conscious control. The autonomic nervous system comprises two subdivisions with opposing functions: the parasympathetic division and the sympathetic division. Generally, the sympathetic division of the autonomic nervous system works to mobilize body activity to meet emergencies, whereas the parasympathetic division is responsible for maintaining body homeostasis at other times.

The central nervous system—the brain and spinal cord—serves as the main processing center for the entire nervous system and controls all the workings of the body. The brain receives sensory input from the spinal cord as well as from its own nerves. Much of its computational power is used to process various sensory inputs and to initiate appropriate and coordinated motor outputs. The spinal cord conducts sensory information from the peripheral nervous system to the brain and also conducts motor information from the brain to various effectors. Nerve impulses reaching the spinal cord are transmitted to higher brain regions. Signals arising in the motor areas of the brain that control movement and other responses travel down the spinal cord to synapse with motor neurons that deliver the stimulus to an organ or muscle. The spinal cord is also the center for certain reflexes in concert with the peripheral nervous system.

The brain is the ultimate controller of all body activities, including physiology and behavior. The brain is subdivided into a number of distinctive components, each with a specific function. The cortex is where neural integration occurs. Responses involving muscle movement are coordinated with another part of the brain called the cerebellum. Central to the brain is the thalamus, which is the center for pain reception and also serves to relay important incoming stimuli to higher parts of the brain. The hypothalamus is responsible for monitoring and maintaining water and mineral balance and appetite. The hippocampus is involved in memory. The deepest part of the brain, the medulla, controls such vital activities as breathing and heart rate.

and the Nervous System

As the nervous system is ultimately responsible for all behavior, physiological function, and reflexes, an analysis of the forensics of the nervous system can have far-reaching consequences and can raise concerns in a number of areas, including injury and sickness, especially as these may relate to accidents or deaths. Specialists in neuropsychiatry, psychopharmacology, and toxicology thus evaluate the nervous system for evidence in cases of traumatic brain injury, post-traumatic stress disorder, and similar disorders that may follow injury.

Forensic investigations regarding the nervous system generally focus on the types and concentrations of chemicals detected in neurological cells and tissue fluids that surround and protect the nervous system. Using techniques of toxicology, forensic analysts evaluate the possible role of toxins or drugs that may affect or impair the nervous system to determine whether any toxins present are related to the or bodily injury. Neuropsychologists are concerned with evaluating basic chemicals in the brain and nervous system to determine whether underlying or root causes of neurological or behavioral disorders may have contributed to the crime or accident being investigated.

Bibliography

DiMaio, Vincent J. M., and Suzanna E. Dana. Handbook of Forensic Pathology. 2d ed. Boca Raton, Fla.: CRC Press, 2007.

Doerr, Hans O., and Albert S. Carlin, eds. Forensic Neuropsychology: Legal and Scientific Bases. New York: Guilford Press, 1991.

Dolinak, David, Evan W. Matshes, and Emma O. Lew. Forensic Pathology: Principles and Practice. Burlington, Mass.: Elsevier Academic Press, 2005.

Haines, Duane E. Fundamental Neuroscience. 2d ed. New York: Churchill Livingstone, 2002.

"In Brief: How Does the Nervous System Work?" National Library of Medicine, 4 May 2023, www.ncbi.nlm.nih.gov/books/NBK279390/. Accessed 19 Aug. 2024.

Kolb, Bryan, and Ian Q. Whishaw. An Introduction to Brain and Behavior. 2d ed. New York: Worth, 2005.

van der Gronde, Toon, et al. "Neurobiological Correlates in Forensic Assessment: A Systemic Review." PLoS One, vol. 9, no. 10, 20 Oct. 2014, doi.org/10.1371%2Fjournal.pone.0110672. Accessed 19 Aug. 2024.

Zheng, Dr. David, et al. "Forensic Neurology: Practice Considerations and Training Opportunities." Neurology, vol. 103, no. 1, 9 July 2024, doi.org/10.1212/WNL.0000000000209560. Accessed 19 Aug. 2024.