Phytochemicals

Biology

Anatomy or system affected: All

Definition: Nonnutritive chemicals produced by plants that provide health benefits to humans who eat plant-derived foods

Protective Role and Abundance

People who eat a diet rich in fresh fruits, vegetables, and whole grains obtain some protection from various diseases because of the phytochemicals that the plants contain. Phytochemicals are not traditional nutrients, such as proteins, carbohydrates, or fats, nor are they vitamins or minerals. Instead, they are substances that plants produce to protect against environmental stresses, such as attack by fungi and other organisms, or to attract animal pollinators or seed dispersers. Many phytochemicals are plant pigments, giving fruits and vegetables their animal-luring colors. There are thousands of phytochemicals, and plant species vary widely in the kinds and amounts that they contain.

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Many phytochemicals have antioxidant properties, meaning that they help protect cells from oxidative damage, which has been implicated in cancer, diabetes, heart disease, strokes, and other disorders. Some phytochemicals function in humans in ways similar to the female hormone estrogen.

Although diets rich in plant-based foods have been shown to result in lower incidences of a number of diseases, scientists have had difficulty pinpointing which of the many different phytochemicals are protective. It may be that the interaction of a variety of naturally occurring phytochemicals, rather than any particular ones, is a significant factor in promoting health.

Well-Known Types

One important group of phytochemicals, carotenoids, includes many antioxidants. Carotenoids may be found in pumpkins, carrots, and bell peppers. Of the numerous health claims that have been made for these plant pigments, one of the few to be substantiated is that increased consumption of lutein, a carotenoid found in green leafy vegetables such as collards, kale, spinach, and broccoli, is associated with a lowered risk for macular degeneration, an eye disease associated with advanced age.

Flavonoids, pigments that belong to a major class of phytochemicals called polyphenols, are abundant in vegetables, fruits such as blueberries and raspberries, and beverages such as tea, red wine, and fruit juices. Some flavonoids, including the widely occurring group anthocyanins, have antioxidant properties. Flavonoids, called isoflavones, are plant estrogens plentiful in soy products.

Other phytonutrients include anthocyanidins, found in red and purple berries; beta-carotene, found in orange and dark green vegetables; catechins, found in apricots and strawberries; isoflavones, found in soybeans; and polyphenols, found in cherries and dark cherries.

Perspective and Prospects

The discovery that phytochemicals are important to human health was not made until late in the twentieth century, and research continues. Scientists do not advise taking dietary supplements of particular phytochemicals but recommend a diet high in a variety of fruits, vegetables, and whole grains. Taking concentrated forms of phytochemicals might be harmful over the long term. Research as of the early 2020s indicated phytochemicals ensure proper functioning of the immune system when infection does occur, and they may reduce inflammation in individuals with inflammatory diseases.

Bibliography

American Institute for Cancer Research, ed. Nutrition and Cancer Prevention: New Insights into the Role of Phytochemicals. Kluwer Academic/Plenum, 2001.

Bao, Yongping, and Roger Fenwick, eds. Phytochemicals in Health and Disease. CRC Press, 2019.

"Foods Containing Phytochemicals." Breastcancer.org, 22 July 2022, www.breastcancer.org/managing-life/diet-nutrition/breast-cancer-risk-reduction/foods/phytochemicals. Accessed 15 July 2023.

Meskin, Mark S., Wayne R. Bidlack, Audra J. Davies, Douglas S. Lewis, and R. Keith Randolph, eds. Phytochemicals: Mechanisms of Action. CRC Press, 2004.

Meskin, Mark S., Wayne R. Bidlack, Audra J. Davies, and Stanley T. Omaye, eds. Phytochemicals in Nutrition and Health. CRC Press, 2002.

Meskin, Mark S., Wayne R. Bidlack, and R. Keith Randolph. “Phytochemicals. Nutrient-Gene Interactions.” Economic Botany, pp. 203–203. doi.org/10.1663/0013-00001.

Webb, Denise. “Phytonutrients: The Hidden Keys to Disease Prevention, Good Health.” Environmental Nutrition, vol. 26, no. 1, Jan. 2003, pp. 1–6.

"What are phytochemicals? (And Why Should You Eat More of Them?)." UCLA Health, 10 May 2023, www.uclahealth.org/news/what-are-phytochemicals-and-why-should-you-eat-more-them. Accessed 15 July 2023.