Sulforaphane's therapeutic uses
Sulforaphane is a natural compound primarily found in broccoli sprouts and other cruciferous vegetables, such as kale and Brussels sprouts. It is being studied for its potential therapeutic uses, including cancer prevention, management of diabetes, and support for cardiovascular and neurological health. Research suggests that a diet rich in these vegetables may be linked to a reduced risk of various cancers, including breast, prostate, and lung cancer, though definitive conclusions are challenging due to the limitations of observational studies.
In addition to its anticancer properties, sulforaphane may improve blood sugar control in diabetes and enhance cardiovascular health by lowering blood pressure and cholesterol. There is also interest in its neuroprotective effects, with some studies investigating its potential benefits for conditions like Alzheimer’s and Parkinson’s disease. While sulforaphane appears to be safe for most individuals, comprehensive safety studies are lacking, particularly for vulnerable populations such as children and pregnant women. Moreover, there is a caution regarding potential interactions with medications, highlighting the importance of consulting a healthcare professional before use. Overall, sulforaphane shows promise, but further research is needed to fully understand its therapeutic potential and safety profile.
Sulforaphane's therapeutic uses
DEFINITION: Natural plant product used to treat specific health conditions.
PRINCIPAL PROPOSED USE: Cancer prevention, diabetes management, cardiovascular health, neurological health
Overview
Sulforaphane is a chemical found in broccoli sprouts and other cabbage-family vegetables, such as broccoli, Brussels sprouts, cabbage, cauliflower, and kale. Some evidence suggests that sulforaphane might help prevent cancer. Several other therapeutic uses for sulforaphane have been suggested.
Requirements and Sources
Sulforaphane is not an essential nutrient. It is found in especially high levels in broccoli sprouts.
Therapeutic Dosages
The proper daily intake (if there is any) of sulforaphane is not known. Typical recommendations range from 200 to 400 micrograms (mcg) daily.
Therapeutic Uses
Numerous studies have found that high consumption of vegetables in the cabbage family is associated with a reduced risk of cancer, especially breast, prostate, lung, stomach, colon, and rectal cancer. On this basis, scientists have looked for anticancer substances in these foods. Sulforaphane is one such candidate substance (indole-3-carbinol, or I3C, is another). In test-tube and animal studies, sulforaphane exhibits properties suggesting it could help prevent many forms of cancer.
However, it is a long way from such studies to reliable evidence of benefit. Observational studies are notoriously poor guides to treatment, sometimes leading to conclusions that are the reverse of what is ultimately found to be correct. The problem is that they cannot show cause and effect; they can show only association. It is possible, for example, that people who consume more cabbage-family vegetables share other traits responsible for reduced cancer rates. Consider the history of hormone replacement therapy. In the 1990s, scientists had concluded that estrogen prevents heart disease, based largely on observational studies that showed menopausal women who use hormone replacement have lower rates of heart disease than women who do not. When double-blind, placebo-controlled studies were performed, however, the results showed that hormone replacement therapy actually increases heart disease risk. For all anyone currently knows, scientists could be making a similar mistake with cabbage-family vegetables.
Certainly, it is too great a leap to single out one constituent of such vegetables and advocate that substance for preventing cancer. Thousands of substances show anticancer properties in the test tube and fail to pan out in real life. The beta-carotene story is another instructive example. Not only did observational studies show that people who consume foods high in beta-carotene have less lung cancer, but test-tube studies found that beta-carotene has anticancer properties. However, subsequent large double-blind studies found that beta-carotene supplements do not help prevent lung cancer and might even increase risk. Conversely, further studies have shown conflicting findings, stating the consumption of foods containing sulforaphane may result in a lowered risk of various types of cancer, as well as improved overall well-being. Cooking with foods containing sulforaphane may improve gut health and promote better intestinal health, but there may be a difference in the benefits based on the source of the consumed sulforaphane.
There have been additional suggested therapeutic uses for sulforaphane besides cancer prevention. Sulforaphane may benefit complications associated with diabetes by improving blood sugar control and increasing insulin sensitivity. Sulforaphane may offer cardiovascular benefits by lowering blood pressure and cholesterol and reducing inflammation from oxidative stress. It may also have neuroprotective benefits that could aid in treating Alzheimer’s and Parkinson’s. Finally, sulforaphane may promote respiratory, digestive, and skin health. Although some double-blind, placebo-controlled studies on sulforaphane exist, they have been mainly confined to investigating its neuroprotective effects, and the results have been mixed. Additionally, studies have looked into the impact of supplementation with sulforaphane on COVID-19 patients.
Safety Issues
No major adverse effects have been reported with sulforaphane supplements, but comprehensive studies have not been performed. Maximum safe doses in young children, pregnant or nursing women, or people with severe liver or kidney disease are not known.
Sulforaphane has shown the potential for interacting with numerous medications. For this reason, it is recommended that individuals taking any oral or injected medication that is critical to their health or well-being avoid using sulforaphane supplements until more is known. Persons who are taking any medication that is critical to their health should not take sulforaphane supplements except under physician supervision.
Bibliography
Alexander, Heather. "Sulforaphane Benefits: How Broccoli and Brussels Sprouts May Help Reduce Your Cancer Risk." The University of Texas MD Anderson Cancer Center, www.mdanderson.org/publications/focused-on-health/sulforaphane-benefits--how-leafy-veggies-like-broccoli-and-bruss.h13-1593780.html. Accessed 16 Sept. 2024.
Abukhabta, S., et al. "Sulforaphane-Enriched Extracts from Glucoraphanin-Rich Broccoli Exert Antimicrobial Activity Against Gut Pathogens in Vitro and Innovative Cooking Methods Increase in Vivo Intestinal Delivery of Sulforaphane." European Journal of Nutrition, vol. 60, 2021, pp. 1263–1276, doi.org/10.1007/s00394-020-02322-0.
Frydoonfar, H. R., D. R. McGrath, and A. D. Spigelman. "The Effect of Indole-3-Carbinol and Sulforaphane on a Prostate Cancer Cell Line." ANZ Journal of Surgery, vol. 73, 2003, pp. 154-156.
Johnston, N. "Sulforaphane Halts Breast Cancer Cell Growth." Drug Discovery Today, vol. 9, 2004, p. 908.
Hei, Gangrui, et al. "Sulforaphane Effects on Cognition and Symptoms in First and Early Episode Schizophrenia: A Randomized Double-Blind Trial." Schizophrenia Bulletin Open, vol. 3, no. 1, 2022, doi.org/10.1093/schizbullopen/sgac024. Accessed 16 Sept. 2024.
Holmes, David. "Could Broccoli Have a Role in Combating Type 2 Diabetes Mellitus?" Nature Reviews Endocrinology, vol. 13, no. 8, 2017, p. 437, doi.org/10.1038/nrendo.2017.86. Accessed 16 Sept. 2024.
Joseph, M. A., et al. "Cruciferous Vegetables, Genetic Polymorphisms in Glutathione S-Transferases M1 and T1, and Prostate Cancer Risk." Nutrition and Cancer, vol. 50, 2004, pp. 206-213.
Yagishita, Yoko, et al. "Broccoli or Sulforaphane: Is It the Source or Dose That Matters?" Molecules, vol. 24, no. 19, Oct. 2019, p. 3593, doi:10.3390/molecules24193593.