Tocotrienols' therapeutic uses
Tocotrienols are naturally occurring compounds related to vitamin E, known for their antioxidant properties. They are being explored for a variety of therapeutic uses, including cancer prevention, cardiovascular health, cholesterol management, and neurological support. While earlier studies suggested potential benefits, such as reducing high cholesterol and aiding in cancer prevention, more recent research has produced mixed results, leading to a reevaluation of tocotrienols' effectiveness for these conditions.
In the 2020s, new studies have highlighted the possibility of tocotrienols supporting bone health, particularly in postmenopausal women, and assisting in stroke recovery. They are also being investigated for their potential role in managing diabetes, enhancing skin health, and promoting hair growth. Despite their promise, definitive conclusions regarding the efficacy of tocotrienols remain to be established, and ongoing clinical trials aim to clarify their health benefits. Overall, tocotrienols continue to garner interest in the scientific community, reflecting a growing curiosity about their role in human health and disease management.
Tocotrienols' therapeutic uses
DEFINITION: Natural plant substances used to treat specific health conditions.
PRINCIPAL PROPOSED USES: None
OTHER PROPOSED USES: Cancer prevention, heart disease prevention, high cholesterol, cardiovascular health, neurological health, chemotherapy support, bone health, diabetes, skin health, hair growth
Overview
Tocotrienols are fat-soluble substances closely related to vitamin E. Like vitamin E, they have antioxidant properties and help protect fatty substances in the body from being damaged by free radicals. In the 1990s, antioxidant supplements were thought to offer great potential for preventing various diseases, including heart disease. On this basis tocotrienols were offered on the market as healthful supplements. Tocotrienols have also been proposed for reducing cholesterol. However, subsequent studies tended to discourage all these reports. In the 2020s, the pendulum has swung somewhat again, with new research showing the potential for positive effects in new areas such as osteoporosis and many others.
Requirements and Sources
Tocotrienols are not essential nutrients. They occur naturally in the oil extract of barley, palm fruit, rice bran, and wheat germ. Most commercially available supplements are made from rice bran oil or palm oil.
Therapeutic Dosages
A typical recommended dose of tocotrienols is 200 milligrams daily.
Therapeutic Uses
While test-tube studies, animal studies, and open human trials seemed to suggest that tocotrienols can correct high cholesterol, properly designed studies failed to find benefit.
Test-tube and animal studies and one double-blind human trial have found promising hints that tocotrienols may help prevent cancer. The double-blind study among these specifically found that tocotrienols might help prevent deoxyribonucleic acid (DNA) damage, which could, in theory, help prevent many diseases associated with aging, not just cancer.
The hypothesis that tocotrienols can prevent heart disease simply by virtue of their antioxidant actions has lost favor since the same hypothesis proved incorrect with vitamin E and beta-carotene. The health benefits of tocotrienols, if there are any, remain to be established fully. Nonetheless, antioxidants are known to neutralize chemicals called free radicals. Free radicals are associated with many adverse conditions, including skin aging, cancer, and chronic inflammation. Therefore, tocotrienol continues to be researched as a potential remedy for these afflictions.
In the twenty-first century, emerging research has indicated several possible therapeutic uses for tocotrienols. Tocotrienols continued to be studied for their cancer prevention benefits and were believed to be a powerful adjuvant therapy for cancer patients looking to reduce the side effects of chemotherapy. Tocotrienols were also being studied for their neuroprotective benefits that could slow the progression of diseases such as Alzheimer's and Parkinson's. Additionally, tocotrienols may aid in stroke recovery, increase bone density in postmenopausal women (suggesting benefits for osteoporosis), help manage blood sugar levels, promote skin health, and encourage hair growth. In the mid-2020s, several double-blind, placebo-controlled trials were being undertaken to investigate these claims.
Safety Issues
Tocotrienols are thought to be safe substances. However, maximum safe doses have not been determined.
Bibliography
Ajuluchukwu, J. N., et al. "Comparative Study of the Effect of Tocotrienols and Tocopherol on Fasting Serum Lipid Profiles in Patients with Mild Hypercholesterolaemia." Nigerian Postgraduate Medical Journal, vol. 14, 2007, pp. 30-33.
Chin, S. F., et al. "Reduction of DNA Damage in Older Healthy Adults by Tri E Tocotrienol Supplementation." Nutrition, vol. 24, no. 1, 2008, pp. 1-10.
Naomi, Ruth, et al. "An Interactive Review on the Role of Tocotrienols in the Neurodegenerative Disorders." Frontiers in Nutrition, vol. 8, 2021, p. 754086, doi.org/10.3389/fnut.2021.754086. Accessed 16 Sept. 2024.
Qureshi, A. A., et al. "Isolation and Identification of Novel Tocotrienols from Rice Bran with Hypocholesterolemic, Antioxidant, and Antitumor Properties." Journal of Agricultural and Food Chemistry, vol. 48, 2000, pp. 3130-3140.
Qureshi, A. A., et al. "Synergistic Effect of Tocotrienol-Rich Fraction (TRF 25) of Rice Bran and Lovastatin on Lipid Parameters in Hypercholesterolemic Humans." Journal of Nutritional Biochemistry, vol. 12, 2001, pp. 318-329.
Shen, Chwan, et al. "Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial." Frontiers in Nutrition, vol. 8, 2021, p. 766711, doi.org/10.3389/fnut.2021.766711. Accessed 16 Sept. 2024.
Szapary, P. O., and M. D. Cirigliano. "Tocotrienols in the Management of Hypercholesterolemia and Atherosclerosis." Alternative Medicine Alert, vol. 3, 2000, pp. 101-105.
Theriault, A., et al. "Tocotrienol: A Review of Its Therapeutic Potential." Clinical Biochemistry, vol. 32, no. 5, 1999, pp. 309-319.
"Vitamin E." Mayo Clinic, 10 Aug. 2023, www.mayoclinic.org/drugs-supplements-vitamin-e/art-20364144. Accessed 16 Sept. 2024.
"Vitamin E for Skin: What does it Do?" Cleveland Clinic, 24 Feb. 2022, health.clevelandclinic.org/vitamin-e-for-skin-health. Accessed 16 Sept. 2024.
Wilson, Debra Rose and Zawn Villines. "What You Need to Know About Tocotrienols." Medical News Today, 14 July 2023, www.medicalnewstoday.com/articles/319689. Accessed 16 Sept. 2024.
Yu, W., et al. "Induction of Apoptosis in Human Breast Cancer Cells by Tocopherols and Tocotrienols." Nutrition and Cancer, vol. 33, 1999, pp. 26-32.