Introduction to dietary supplements

DEFINITION: Dietary supplements used to promote health.

Overview

One of the twentieth century's great medical discoveries was identifying the nutritional substances necessary for life. Along with the macronutrients (fat, carbohydrate, and protein), these nutritional supplements, or micronutrients, make up the essential ingredients of a healthy diet. Supplements include pills, powders, gummies, flavored liquids, bars, and patches, and they are most commonly classified as a vitamin, mineral, botanical or herb, botanical compound, amino acid, or a live microbe.

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Vitamins and minerals have been available as supplements since the 1930s. In the 1960s, however, a new way of using supplements came into vogue: megadose therapy. The megadose approach involves taking supplements at doses far above nutrition needs in hopes of producing a specific medical benefit. Essentially, megadose therapy means using nutrients as natural drugs.

The original (and still important) method of using nutrients involves taking them at around the level of nutrition needs. This method may be considered nutrition insurance for the majority of people who do not get all the nutrients they need from food. The dietary supplement industry continued to expand in the twenty-first century, and with that expansion came medical and ethical implications that presented myriad issues. Responsible supplementation for dietary needs is one of the conveniences of medicine in the twenty-first century, but patients must remain informed about their bodies’ needs and what substances they decide to ingest.

The global dietary supplement manufacturing industry is a multi-billion dollar business, and in the United States, supplements are not regulated as drugs. This means the quality, efficacy, and safety of each brand and type of supplement is relatively unknown. While the US Food and Drug Administration provides supplement manufacturers with good manufacturing practices guidelines, it is important for consumers to remain vigilant and informed about the contents of the supplements they consume.

Finally, there are a number of substances that are sold as supplements but are not nutritional in nature. While these substances might offer health benefits, one does not need them to stay alive. Examples include isoflavones, which are chemicals found in soy that may reduce the risk of cancer and some forms of heart disease; glucosamine, which is a substance found in gristle that is useful for osteoarthritis; and melatonin, a hormone that is not found to any great extent in foods but is helpful for sleep.

Bibliography

“Dietary Supplements.” U.S. Food and Drug Administration, 21 Feb. 2024, www.fda.gov/food/dietary-supplements. Accessed 20 Sept. 2024.

"Dietary Supplements: What You Need to Know." National Institutes of Health, 4 Jan. 2023, ods.od.nih.gov/factsheets/WYNTK-Consumer. Accessed 20 Sept. 2024.

"FDA 101: Dietary Supplements." U.S. Food and Drug Administration, 2022, www.fda.gov/consumers/consumer-updates/fda-101-dietary-supplements. Accessed 20 Sept. 2024.

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Jerome-Morais, A., et al. “Dietary Supplements and Human Health: For Better or for Worse?” Molecular Nutrition and Food Research, 1 Dec. 2010.

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Melillo, Gianna. “The Nutritional Supplements Industry is Booming, but Experts Warn It Presents Risks.” The Hill, 30 Aug. 2022, thehill.com/changing-america/well-being/prevention-cures/3619897-the-nutritional-supplements-industry-is-booming-but-experts-warn-it-presents-risks. Accessed 21 Aug. 2023.

Skidmore-Roth, Linda. Mosby’s Handbook of Herbs and Supplements. 4th ed., Mosby/Elsevier, 2010.

Ströhle, A., K. Zänker, and A. Hahn. “Nutrition in Oncology: The Case of Micronutrients (Review).” Oncology Reports, vol. 24, 2010, pp. 815-28.

Zlotkin, S., et al. “The Role of the Codex Alimentarius Process in Support of New Products to Enhance the Nutritional Health of Infants and Young Children.” Food and Nutrition Bulletin, vol. 31, suppl. 2, 2010, pp. S128-33.